Three-Axis Model for Atg Recruitment in Autophagy against Salmonella

Abstract EN

Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there.

Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella-containing vacuole (SCV).

In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella.

The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex.

In the absence of Atg9L1, FIP200, and PI3-kinase activity, LC3 is still recruited to the vicinity of Salmonella.

We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane.

There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atg16L complex.