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Synthesis and Characterization of a New Five and Six Membered Selenoheterocyclic Compounds Homologues of Ebselen
Joint Authors
Messali, Mouslim
Christiaens, Léon E.
Abboudi, Mostafa
Aouad, Mohamed R.
Rezki, Nadjet
Source
Organic Chemistry International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The discovery of the antioxidant activity of selenoenzyme glutathione peroxidase (GPx) has attracted growing attention in the biochemistry of selenium.
Among molecules which mimic the structure of the active site of the enzyme, N-phenyl-1,2-benzisoselenazolin-3-one 1, Ebselen, exhibited useful anti-inflammatory properties.
It has been extensively investigated and has undergone clinical trials as an anti-inflammatory agent.
Unfortunately, Ebselen exhibits relatively poor catalytic activity, prompting attempts to design more efficacious GPx mimetics that would retain his low toxicity while manifesting improved catalytic properties.
In this context, novel 1,2-benzoselenazine and 1,2-benzoselenazols, which are five and six membered homologues of Ebselen were synthesized and characterized.
One structure has been proven by single crystal X-ray crystallography.
American Psychological Association (APA)
Messali, Mouslim& Abboudi, Mostafa& Aouad, Mohamed R.& Rezki, Nadjet& Christiaens, Léon E.. 2012. Synthesis and Characterization of a New Five and Six Membered Selenoheterocyclic Compounds Homologues of Ebselen. Organic Chemistry International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-468260
Modern Language Association (MLA)
Messali, Mouslim…[et al.]. Synthesis and Characterization of a New Five and Six Membered Selenoheterocyclic Compounds Homologues of Ebselen. Organic Chemistry International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-468260
American Medical Association (AMA)
Messali, Mouslim& Abboudi, Mostafa& Aouad, Mohamed R.& Rezki, Nadjet& Christiaens, Léon E.. Synthesis and Characterization of a New Five and Six Membered Selenoheterocyclic Compounds Homologues of Ebselen. Organic Chemistry International. 2012. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-468260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468260