Strength-Duration Time Constant in Peripheral Nerve : No Abnormality in Multiple Sclerosis
Joint Authors
Bek, Semai
Demirkaya, Seref
Ulas, Umit Hidir
Odabasi, Zeki
Genç, Gençer
Kasikci, Tayfun
Source
Multiple Sclerosis International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To investigate the properties of the strength-duration time constant (SDTC) in multiple sclerosis (MS) patients.
Methods.
The SDTC and rheobase in 16 MS patients and 19 healthy controls were obtained following stimulation of the right median nerve at the wrist.
Results.
SDTC and rheobase values were 408.3±60.0 μs and 4.0±1.8 mA in MS patients, versus 408.0±62.4 μs and 3.8±2.1 mA in controls.
The differences were not significant in SDTC or rheobase values between the patients and controls (P=0.988 for SDTC and P=0.722 for rheobase).
Conclusion.
Our study showed no abnormality in relapsing remitting MS patients in terms of SDTC, which gives some indirect information about peripheral Na+ channel function.
This may indicate that alterations in the Na+ channel pattern in central nervous system (CNS) couldnot be shown in the peripheral nervous system (PNS) in the MS patients by SDTC.
The opinion that MS can be a kind of channelopathy might be proven by performing other axonal excitability tests or SDTC in progressive forms of MS.
American Psychological Association (APA)
Genç, Gençer& Bek, Semai& Kasikci, Tayfun& Ulas, Umit Hidir& Demirkaya, Seref& Odabasi, Zeki. 2012. Strength-Duration Time Constant in Peripheral Nerve : No Abnormality in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468296
Modern Language Association (MLA)
Genç, Gençer…[et al.]. Strength-Duration Time Constant in Peripheral Nerve : No Abnormality in Multiple Sclerosis. Multiple Sclerosis International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-468296
American Medical Association (AMA)
Genç, Gençer& Bek, Semai& Kasikci, Tayfun& Ulas, Umit Hidir& Demirkaya, Seref& Odabasi, Zeki. Strength-Duration Time Constant in Peripheral Nerve : No Abnormality in Multiple Sclerosis. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468296