External Beam Therapy in a Four-Field Box Technique with Paclitaxel versus a Two-Field Technique with Cisplatin in Locally Advanced Carcinoma Cervix : A Phase II Monocentric Trial
Joint Authors
Narayanan, Vijayakumar
Sharma, Samir
Bista, Bibek
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
External beam pelvic radiotherapy with cisplatin and brachytherapy is the standard of care for patients with advanced cervical malignancy.
This study was aimed at evaluating the toxicity of a two-field radiotherapy with cisplatin and brachytherapy compared to a four-field box technique with paclitaxel and brachytherapy for stages IIB/IIIB cervical cancer.
The differences in response to the overall treatment were also examined.
Methods.
35 patients were enrolled in this phase II prospective randomized trial conducted from February 2006 to February 2007.
In arm I, up to 40 Gy in 20 fractions followed by 10 Gy in 5 fractions in split field with cisplatin 40 mg/M2 and, in arm II, 50 Gy in 25 fractions with paclitaxel 50 mg/M2 were given.
Results.
Toxicity in genitourinary, lower gastrointestinal, and hematological tissues was significantly higher in arm I.
The duration of concurrent chemoradiotherapy in either arm was similar.
The overall treatment time was less in arm II.
No statistically significant difference in the objective response was observed between arms.
Conclusion.
Two-field radiotherapy with cisplatin is a tolerable regime but more toxic than four-field box radiotherapy with paclitaxel.
The major setbacks are that a radiotherapy technique as well as chemotherapy is different; hence, toxicity and outcome of treatment should be viewed as a collective response of the whole treatment regimen and the small sample size.
American Psychological Association (APA)
Narayanan, Vijayakumar& Bista, Bibek& Sharma, Samir. 2012. External Beam Therapy in a Four-Field Box Technique with Paclitaxel versus a Two-Field Technique with Cisplatin in Locally Advanced Carcinoma Cervix : A Phase II Monocentric Trial. ISRN Oncology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468300
Modern Language Association (MLA)
Narayanan, Vijayakumar…[et al.]. External Beam Therapy in a Four-Field Box Technique with Paclitaxel versus a Two-Field Technique with Cisplatin in Locally Advanced Carcinoma Cervix : A Phase II Monocentric Trial. ISRN Oncology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-468300
American Medical Association (AMA)
Narayanan, Vijayakumar& Bista, Bibek& Sharma, Samir. External Beam Therapy in a Four-Field Box Technique with Paclitaxel versus a Two-Field Technique with Cisplatin in Locally Advanced Carcinoma Cervix : A Phase II Monocentric Trial. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468300