Role of AMPKα in Skeletal Muscle Glycometabolism Regulation and Adaptation in relation to Sepsis
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
AMP-activated protein kinase (AMPK) and the translocation of glucose transporter 4 (GLUT4) protein always involve disturbance of carbohydrate metabolism.
Objective.
To determine whether the change of blood glucose in the early stage of septic rat is associated with the alteration of AMPKα protein expression and GLUT4 protein translocation expression.
Methods.
Animal models of sepsis were induced by tail vein injection of LPS in Wistar rats.
The dynamic values of blood glucose within 2 hours after injection of LPS were observed.
AMPKα protein and GLUT4 protein translocation in different tissues (such as soleus muscle and extensor digitorum longus) were assessed by western blot.
Results.
Blood glucose levels appeared to rise at 0.5 h after injection of LPS, arrived the peak value at 1 h, then fell at 1.5 h and 2 h Animals in LPS group experienced the increase of phos-AMPKα protein and GLUT4 protein translocation expression in soleus muscle and extensor digitorum longus.
Conclusion.
The dynamic change of blood glucose, represented in a form of initiative increase and subsequent decrease in the early stage of sepsis, may be related to glycometabolism disorder in the skeletal muscle, coming down to enhancement of GLUT4 translocation expression promoted by activation of AMPKα.
American Psychological Association (APA)
Zheng, Xia& Xu, Mi& Fang, Qiang. 2014. Role of AMPKα in Skeletal Muscle Glycometabolism Regulation and Adaptation in relation to Sepsis. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-468354
Modern Language Association (MLA)
Zheng, Xia…[et al.]. Role of AMPKα in Skeletal Muscle Glycometabolism Regulation and Adaptation in relation to Sepsis. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-468354
American Medical Association (AMA)
Zheng, Xia& Xu, Mi& Fang, Qiang. Role of AMPKα in Skeletal Muscle Glycometabolism Regulation and Adaptation in relation to Sepsis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-468354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468354