Outcome and Prognostic Factors in T4a Oropharyngeal Carcinoma, Including the Role of HPV Infection
Joint Authors
Iro, Heinrich
Psychogios, Georgios
Zenk, Johannes
Brunner, Kathrin
Agaimy, Abbas
Mangold, Elisabeth
Mantsopoulos, Konstantinos
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The prognosis of patients with advanced oropharyngeal carcinoma (OPSCC) is generally poor.
The aim of this study is to investigate the different therapeutic approaches and identify prognostic factors associated with a worse outcome for patients treated for T4a OPSCC, in order to improve treatment selection for the individual.
Methods.
A retrospective study was conducted on 426 patients with T4a OPC treated between 1980 and 2010.
Eleven prognostic factors including treatment modality, lymph node staging, and p16 status as a surrogate marker for human papillomavirus (HPV) infection were analyzed.
Results.
Univariate analysis showed a significant difference in DSS between N0 and N+ (57.1% versus 26.9%, P<0.001), primary surgical and primary nonsurgical treatment (52.7% versus 31.4%, P<0.001), and perinodal invasion (51.7% versus 19.9%, P=0.011).
P16-negative patients tended towards a worse DSS than p16-positive patients (40.2% versus 64.6%, P=0.126) but responded better to primary surgery than to nonsurgical treatment (71.4% versus 34.0%, P=0.113).
Multivariate analysis identified the N category as an independent prognostic factor for survival.
Conclusion.
The survival of p16-negative patients was worse than p16-positive patients, although they seem to respond better to primary surgery.
The strongest independent prognostic factor for T4a carcinomas proved to be the presence of lymph node metastases.
American Psychological Association (APA)
Psychogios, Georgios& Mantsopoulos, Konstantinos& Agaimy, Abbas& Brunner, Kathrin& Mangold, Elisabeth& Zenk, Johannes…[et al.]. 2014. Outcome and Prognostic Factors in T4a Oropharyngeal Carcinoma, Including the Role of HPV Infection. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-468362
Modern Language Association (MLA)
Psychogios, Georgios…[et al.]. Outcome and Prognostic Factors in T4a Oropharyngeal Carcinoma, Including the Role of HPV Infection. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-468362
American Medical Association (AMA)
Psychogios, Georgios& Mantsopoulos, Konstantinos& Agaimy, Abbas& Brunner, Kathrin& Mangold, Elisabeth& Zenk, Johannes…[et al.]. Outcome and Prognostic Factors in T4a Oropharyngeal Carcinoma, Including the Role of HPV Infection. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-468362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468362