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Mapping Metabolic Brain Activity in Three Models of Hepatic Encephalopathy
Joint Authors
Arias, Natalia
Fidalgo, Camino
Aller, María Ángeles
Arias, Jaime
Arias, Jorge L.
Méndez, Marta
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cirrhosis is a common disease in Western countries.
Liver failure, hyperammonemia, and portal hypertension are the main factors that contribute to human cirrhosis that frequently leads to a neuropsychiatric disorder known as hepatic encephalopathy (HE).
In this study, we examined the differential contribution of these leading factors to the oxidative metabolism of diverse brain limbic system regions frequently involved in memory process by histochemical labelling of cytochrome oxidase (COx).
We have analyzed cortical structures such as the infralimbic and prelimbic cotices, subcortical structures such as hippocampus and ventral striatum, at thalamic level like the anterodorsal, anteroventral, and mediodorsal thalamus, and, finally, the hypothalamus, where the mammillary nuclei (medial and lateral) were measured.
The severest alteration is found in the model that mimics intoxication by ammonia, followed by the thioacetamide-treated group and the portal hypertension group.
No changes were found at the mammillary bodies for any of the experimental groups.
American Psychological Association (APA)
Arias, Natalia& Méndez, Marta& Fidalgo, Camino& Aller, María Ángeles& Arias, Jaime& Arias, Jorge L.. 2013. Mapping Metabolic Brain Activity in Three Models of Hepatic Encephalopathy. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-468368
Modern Language Association (MLA)
Arias, Natalia…[et al.]. Mapping Metabolic Brain Activity in Three Models of Hepatic Encephalopathy. International Journal of Hypertension No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-468368
American Medical Association (AMA)
Arias, Natalia& Méndez, Marta& Fidalgo, Camino& Aller, María Ángeles& Arias, Jaime& Arias, Jorge L.. Mapping Metabolic Brain Activity in Three Models of Hepatic Encephalopathy. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-468368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468368