Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway
Joint Authors
Zhuang, Jian
Zhang, Xiaoyu
Li, Ji
Zhu, Ping
Guo, Hui-Ming
Li, Wenguang
Bucala, Richard
Zhang, Xiuying
Chen, Ji-Mei
Ma, Yina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco.
Reactive oxygen species (ROS) is a critical factor involved in modulating cardiac stress response signaling during ischemia and reperfusion.
We hypothesize that ISL as a natural antioxidant may protect heart against ischemic injury via modulating cellular redox status and regulating cardioprotective signaling pathways.
The fluorescent probe H2DCFDA was used to measure the level of intracellular ROS.
The glucose uptake was determined by 2-deoxy-D-glucose-3H accumulation.
The IonOptix System measured the contractile function of isolated cardiomyocytes.
The results demonstrated that ISL treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia.
ISL significantly stimulated cardioprotective signaling, AMP-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK) signaling pathways.
The ROS fluorescent probe H2DCFDA determination indicated that ISL significantly reduced cardiac ROS level during hypoxia/reoxygenation.
Moreover, ISL reduced the mitochondrial potential (Δψ) of isolated mouse cardiomyocytes.
Taken together, ISL as a natural antioxidant demonstrated the cardioprotection against ischemic injury that may attribute to the activation of AMPK and ERK signaling pathways and balance of cellular redox status.
American Psychological Association (APA)
Zhang, Xiaoyu& Zhu, Ping& Zhang, Xiuying& Ma, Yina& Li, Wenguang& Chen, Ji-Mei…[et al.]. 2013. Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468371
Modern Language Association (MLA)
Zhang, Xiaoyu…[et al.]. Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-468371
American Medical Association (AMA)
Zhang, Xiaoyu& Zhu, Ping& Zhang, Xiuying& Ma, Yina& Li, Wenguang& Chen, Ji-Mei…[et al.]. Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468371