Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension
Joint Authors
Penz, Peter
Bernadic, Marian
Lietava, Jan
Bucova, Maria
Mrazek, Frantisek
Petrkova, Jana
Petrek, Martin
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects.
Totally, 263 patients with the diagnosis of IHD, out of them 89 with MI, 145 with AP, 205 with HT, and also 67 healthy subjects were included in the study.
First, we estimated the serum levels of hsCRP.
We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P=.043) and IHD patients without AP (P=.026).
The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P=.016), AP (P=.004), and HT (P=.013).
Higher correlations were found in men (AP: P=.019; HT: P=.047).
In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.
American Psychological Association (APA)
Bucova, Maria& Lietava, Jan& Penz, Peter& Mrazek, Frantisek& Petrkova, Jana& Bernadic, Marian…[et al.]. 2009. Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-468379
Modern Language Association (MLA)
Bucova, Maria…[et al.]. Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension. Mediators of Inflammation No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-468379
American Medical Association (AMA)
Bucova, Maria& Lietava, Jan& Penz, Peter& Mrazek, Frantisek& Petrkova, Jana& Bernadic, Marian…[et al.]. Association of MCP-1 -2518 AG Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-468379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468379