Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice
Joint Authors
Syberg, Susanne
Jensen, Jens-Erik Beck
Schwarz, Peter
Petersen, Solveig
Gartland, Alison
Chessell, Iain
Teilmann, Jenni
Steinberg, Thomas H.
Jorgensen, Niklas Rye
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The purinergic P2X7 receptor is expressed by bone cells and has been shown to be important in both bone formation and bone resorption.
In this study we investigated the importance of the genetic background of the mouse strains on which the P2X7 knock-out models were based by comparing bone status of a new BALB/cJ P2X7−/− strain with a previous one based on the C57BL/6 strain.
Female four-month-old mice from both strains were DXA scanned on a PIXImus densitometer; femurs were collected for bone strength measurements and serum for bone marker analysis.
Bone-related parameters that were altered only slightly in the B6 P2X7−/− became significantly altered in the BALB/cJ P2X7−/− when compared to their wild type littermates.
The BALB/cJ P2X7−/− showed reduced levels of serum C-telopeptide fragment (s-CTX), higher bone mineral density, and increased bone strength compared to the wild type littermates.
In conclusion, we have shown that the genetic background of P2X7−/− mice strongly influences the bone phenotype of the P2X7−/− mice and that P2X7 has a more significant regulatory role in bone remodeling than found in previous studies.
American Psychological Association (APA)
Syberg, Susanne& Petersen, Solveig& Jensen, Jens-Erik Beck& Gartland, Alison& Teilmann, Jenni& Chessell, Iain…[et al.]. 2012. Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice. Journal of Osteoporosis،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-468397
Modern Language Association (MLA)
Syberg, Susanne…[et al.]. Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice. Journal of Osteoporosis No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-468397
American Medical Association (AMA)
Syberg, Susanne& Petersen, Solveig& Jensen, Jens-Erik Beck& Gartland, Alison& Teilmann, Jenni& Chessell, Iain…[et al.]. Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice. Journal of Osteoporosis. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-468397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468397