Conformation and Physical Structure of Tropoelastin from Human Vascular Cells : Influence of Cells Lipid Loading
Joint Authors
Lacabanne, Colette
Samouillan, Valerie
Badimon, Lina
Dandurand, Jany
Nasarre, Laura
Llorente-Cortés, Vicenta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Aggregated low density lipoproteins (agLDL) contribute to massive intracellular cholesteryl ester (CE) accumulation in human vascular smooth muscle cells (VSMC).
Our aim was to determine the conformational and physical structure of agLDL and elastic material produced either by control human VSMC or by agLDL-loaded human VSMC (agLDL-VSMC).
At the conformational level scanned by FTIR spectroscopy, a new undefined, probably non-H-bonded, structure for tropoelastin produced by agLDL-VSMC is revealed.
By differential scanning calorimetry, a decrease of water affinity and a drop of the glass transition associated with aggregated tropoelastin (from 200°C to 159°C) in the supernatant from agLDL VSMC are evidenced.
This second phenomenon is due to an interaction between agLDL and tropoelastin as detected by the weak specific FTIR absorption band of agLDL in supernatant from agLDL-loaded VSMC.
American Psychological Association (APA)
Samouillan, Valerie& Dandurand, Jany& Nasarre, Laura& Badimon, Lina& Lacabanne, Colette& Llorente-Cortés, Vicenta. 2014. Conformation and Physical Structure of Tropoelastin from Human Vascular Cells : Influence of Cells Lipid Loading. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-468401
Modern Language Association (MLA)
Samouillan, Valerie…[et al.]. Conformation and Physical Structure of Tropoelastin from Human Vascular Cells : Influence of Cells Lipid Loading. Conference Papers in Science No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-468401
American Medical Association (AMA)
Samouillan, Valerie& Dandurand, Jany& Nasarre, Laura& Badimon, Lina& Lacabanne, Colette& Llorente-Cortés, Vicenta. Conformation and Physical Structure of Tropoelastin from Human Vascular Cells : Influence of Cells Lipid Loading. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-468401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468401