Mouse Model Resources for Vision Research
Joint Authors
Hurd, Ronald
Shi, Lan Ying
Chang, Bo
Hicks, Wanda
Won, Jungyeon
Wang, Jieping
Naggert, Jürgen K.
Nishina, Patsy M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The need for mouse models, with their well-developed genetics and similarity to human physiology and anatomy, is clear and their central role in furthering our understanding of human disease is readily apparent in the literature.
Mice carrying mutations that alter developmental pathways or cellular function provide model systems for analyzing defects in comparable human disorders and for testing therapeutic strategies.
Mutant mice also provide reproducible, experimental systems for elucidating pathways of normal development and function.
Two programs, the Eye Mutant Resource and the Translational Vision Research Models, focused on providing such models to the vision research community are described herein.
Over 100 mutant lines from the Eye Mutant Resource and 60 mutant lines from the Translational Vision Research Models have been developed.
The ocular diseases of the mutant lines include a wide range of phenotypes, including cataracts, retinal dysplasia and degeneration, and abnormal blood vessel formation.
The mutations in disease genes have been mapped and in some cases identified by direct sequencing.
Here, we report 3 novel alleles of Crxtvrm65, Rp1tvrm64, and Rpe65tvrm148 as successful examples of the TVRM program, that closely resemble previously reported knockout models.
American Psychological Association (APA)
Won, Jungyeon& Shi, Lan Ying& Hicks, Wanda& Wang, Jieping& Hurd, Ronald& Naggert, Jürgen K.…[et al.]. 2010. Mouse Model Resources for Vision Research. Journal of Ophthalmology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-468412
Modern Language Association (MLA)
Won, Jungyeon…[et al.]. Mouse Model Resources for Vision Research. Journal of Ophthalmology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-468412
American Medical Association (AMA)
Won, Jungyeon& Shi, Lan Ying& Hicks, Wanda& Wang, Jieping& Hurd, Ronald& Naggert, Jürgen K.…[et al.]. Mouse Model Resources for Vision Research. Journal of Ophthalmology. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-468412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468412