Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line
Joint Authors
Chen, Long
Zhang, Wen
Yao, Can
Zhang, Guang-Sen
Li, Zi-Jian
Xi, Ya-Ming
Liu, Su-Fang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Icaritin (ICT), a hydrolytic product of icariin from Epimedium genus, exhibits antitumor activities in several human solid-tumor and myeloid leukemia cells with extensive influence on various cell signal molecules, such as MAPKs being involved in cell proliferation and Bcl-2 participating in cell apoptosis.
However, the effect of icaritin on Burkitt Lymphoma has not been elucidated.
In the present study, we first screened the potential effect of icaritin on Burkitt lymphoma Raji and P3HR-1 cell lines and found that icaritin showed cytotoxicity in both cell lines.
We further found that icaritin could significantly inhibit Raji cells proliferation with S-phase arrest of cell cycle and induced cell apoptosis accompanied by activation of caspase-8 and caspase-9 and cleavage of PARP.
We also observed that icaritin was able to decrease Bcl-2 levels, thus shifting the Bcl-2/Bax ratio, and it could obviously reduce c-Myc, a specific molecular target in Burkitt lymphoma.
Our findings demonstrated that icaritin showed cytotoxicity, inhibited cell growth, caused S arrest, and induced apoptosis in Burkitt lymphoma cells and provided a rationale for the further evaluation of icaritin for Burkitt lymphoma therapy.
American Psychological Association (APA)
Li, Zi-Jian& Yao, Can& Liu, Su-Fang& Chen, Long& Xi, Ya-Ming& Zhang, Wen…[et al.]. 2014. Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468424
Modern Language Association (MLA)
Li, Zi-Jian…[et al.]. Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-468424
American Medical Association (AMA)
Li, Zi-Jian& Yao, Can& Liu, Su-Fang& Chen, Long& Xi, Ya-Ming& Zhang, Wen…[et al.]. Cytotoxic Effect of Icaritin and Its Mechanisms in Inducing Apoptosis in Human Burkitt Lymphoma Cell Line. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468424