Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats
Joint Authors
Abdull Razis, Ahmad Faizal
Konsue, Nattaya
Mohd Noor, Noramaliza
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Phenethyl isothiocyanate (PEITC) is an isothiocyanate found in watercress as the glucosinolate (gluconasturtiin).
The isothiocyanate is converted from the glucosinolate by intestinal microflora or when contacted with myrosinase during the chopping and mastication of the vegetable.
PEITC manifested protection against chemically-induced cancers in various tissues.
A potential mechanism of chemoprevention is by modulating the metabolism of carcinogens so as to promote deactivation.
The principal objective of this study was to investigate in rats the effect of PEITC on carcinogen-metabolising enzyme systems such as sulfotransferase (SULT), N-acetyltransferase (NAT), glucuronosyl transferase (UDP), and epoxide hydrolase (EH) following exposure to low doses that simulate human dietary intake.
Rats were fed for 2 weeks diets supplemented with PEITC at 0.06 µmol/g (low dose, i.e., dietary intake), 0.6 µmol/g (medium dose), and 6.0 µmol/g (high dose), and the enzymes were monitored in rat liver.
At the Low dose, no induction of the SULT, NAT, and EH was noted, whereas UDP level was elevated.
At the Medium dose, only SULT level was increased, whereas at the High dose marked increase in EH level was observed.
It is concluded that PEITC modulates carcinogen-metabolising enzyme systems at doses reflecting human intake thus elucidating the mechanism of its chemoprevention.
American Psychological Association (APA)
Abdull Razis, Ahmad Faizal& Mohd Noor, Noramaliza& Konsue, Nattaya. 2014. Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-468426
Modern Language Association (MLA)
Abdull Razis, Ahmad Faizal…[et al.]. Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-468426
American Medical Association (AMA)
Abdull Razis, Ahmad Faizal& Mohd Noor, Noramaliza& Konsue, Nattaya. Induction of Epoxide Hydrolase, Glucuronosyl Transferase, and Sulfotransferase by Phenethyl Isothiocyanate in Male Wistar Albino Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-468426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468426