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Rheumatoid Arthritis and Primary Biliary Cirrhosis : Cause, Consequence, or Coincidence?
Joint Authors
Mytilinaiou, Maria G.
Bogdanos, Dimitrios P.
Smyk, Daniel S.
Rigopoulou, Eirini I.
Burroughs, Andrew K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized serologically by cholestasis and the presence of high-titre antimitochondrial antibodies and histologically by chronic nonsuppurative cholangitis and granulomata.
PBC patients often have concomitant autoimmune diseases, including arthropathies.
This raises the question as to whether there are shared features in the pathogenesis of those diseases with the pathogenesis of PBC.
Epidemiological and large case studies have indicated that although the incidence of rheumatoid arthritis (RA) is not significantly raised in PBC patients, there appears to be a higher rate of RA in PBC patients and their relatives.
Genetic studies have demonstrated that several genes implicated in PBC have also been implicated in RA.
Epigenetic studies provided a wealth of data regarding RA, but the findings on epigenetic changes in PBC are very limited.
As well, certain infectious agents identified in the pathogenesis of PBC may also play a role in the pathogenesis of RA.
These data suggest that although RA is not significantly present in PBC, some individuals with certain genetic traits and environmental exposures may develop both conditions.
This concept may also apply to other concomitant diseases found in PBC patients.
American Psychological Association (APA)
Smyk, Daniel S.& Bogdanos, Dimitrios P.& Mytilinaiou, Maria G.& Burroughs, Andrew K.& Rigopoulou, Eirini I.. 2012. Rheumatoid Arthritis and Primary Biliary Cirrhosis : Cause, Consequence, or Coincidence?. Arthritis،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468432
Modern Language Association (MLA)
Smyk, Daniel S.…[et al.]. Rheumatoid Arthritis and Primary Biliary Cirrhosis : Cause, Consequence, or Coincidence?. Arthritis No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-468432
American Medical Association (AMA)
Smyk, Daniel S.& Bogdanos, Dimitrios P.& Mytilinaiou, Maria G.& Burroughs, Andrew K.& Rigopoulou, Eirini I.. Rheumatoid Arthritis and Primary Biliary Cirrhosis : Cause, Consequence, or Coincidence?. Arthritis. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468432