Chopper Is Prodeath Regardless of the Effect of p75ICD on Sensitivity to Oxidative Stress
Joint Authors
Mi, Zhiping
Halterman, Marc W.
Qazi, Alliya
Zhang, Tong
Schor, Nina F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
The intracellular domain (ICD) of the neurotrophin receptor, p75NTR, exhibits variably pro- and antiapoptotic activity and has been implicated in neurodegenerative and neurodestructive disease.
The molecular determinants of these cellular effects are not completely understood.
The “Chopper” domain of p75ICD has been shown to be proapoptotic in in vitro systems in which p75ICD is proapoptotic.
The effects of Chopper in systems in which p75ICD is antiapoptotic and, therefore, whether or not Chopper accounts for the variability of the cellular effects of p75ICD are not known.
We therefore examined the effects of deletion of Chopper on the effects of p75ICD on in vitro cell culture systems in which p75ICD is pro- or antiapoptotic, respectively.
Results.
In HN33.11 murine neuroblastoma-hippocampal neuron hybrid cells, p75ICD is antiapoptotic.
In NIH 3T3 cells, p75ICD is proapoptotic.
In both cell lines deletion of the Chopper domain from p75ICD decreases the incidence of apoptosis resulting from oxidative stress.
Thus, irrespective of the nature of the effects of p75ICD on the cell, its Chopper domain is proapoptotic.
Conclusions.
Expression of p75ICD can enhance or attenuate oxidative induction of apoptosis.
Variability of the effects of p75ICD is not related to variability of the effects of its Chopper domain.
American Psychological Association (APA)
Qazi, Alliya& Halterman, Marc W.& Mi, Zhiping& Zhang, Tong& Schor, Nina F.. 2011. Chopper Is Prodeath Regardless of the Effect of p75ICD on Sensitivity to Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468455
Modern Language Association (MLA)
Qazi, Alliya…[et al.]. Chopper Is Prodeath Regardless of the Effect of p75ICD on Sensitivity to Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468455
American Medical Association (AMA)
Qazi, Alliya& Halterman, Marc W.& Mi, Zhiping& Zhang, Tong& Schor, Nina F.. Chopper Is Prodeath Regardless of the Effect of p75ICD on Sensitivity to Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468455