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Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport
Joint Authors
Horita, Shoko
Koike, Kazuhiko
Fujita, Toshiro
Seki, George
Suzuki, Masashi
Yamada, Hideomi
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sodium transport through various nephron segments is quite important in regulating sodium reabsorption and blood pressure.
Among several regulators of this process, insulin acts on almost all the nephron segments and is a strong enhancer of sodium reabsorption.
Sodium-proton exchanger type 3 (NHE3) is a main regulator of sodium reabsorption in the luminal side of proximal tubule.
In the basolateral side of the proximal tubule, sodium-bicarbonate cotransporter (NBCe1) mediates sodium and bicarbonate exit from tubular cells.
In the distal nephron and the connecting tubule, epithelial sodium channel (ENaC) is of great importance to sodium reabsorption.
NHE3, NBCe1, and ENaC are all regulated by insulin.
Recently with-no-lysine (WNK) kinases, responsible for familial hypertension, stimulating sodium reabsorption in the distal nephron, have been found to be also regulated by insulin.
We will discuss the regulation of renal sodium transport by insulin and its roles in the pathogenesis of hypertension in insulin resistance.
American Psychological Association (APA)
Horita, Shoko& Seki, George& Yamada, Hideomi& Suzuki, Masashi& Koike, Kazuhiko& Fujita, Toshiro. 2011. Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468464
Modern Language Association (MLA)
Horita, Shoko…[et al.]. Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport. International Journal of Hypertension No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468464
American Medical Association (AMA)
Horita, Shoko& Seki, George& Yamada, Hideomi& Suzuki, Masashi& Koike, Kazuhiko& Fujita, Toshiro. Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468464