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The Role of GABAergic Inhibition in Ocular Dominance Plasticity
Joint Authors
Levelt, Christiaan N.
Heimel, J. Alexander
van Versendaal, Daniëlle
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex.
This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disorders caused by defective synaptic plasticity.
One of the central mechanisms responsible for opening the sensitive period is the maturation of inhibitory innervation.
Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation.
The mechanisms through which the development of inhibitory innervation triggers and potentially closes the sensitive period may involve plasticity of inhibitory inputs or permissive regulation of excitatory synapse plasticity.
Here, we discuss the current state of knowledge in the field and open questions to be addressed.
American Psychological Association (APA)
Heimel, J. Alexander& van Versendaal, Daniëlle& Levelt, Christiaan N.. 2011. The Role of GABAergic Inhibition in Ocular Dominance Plasticity. Neural Plasticity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-468465
Modern Language Association (MLA)
Heimel, J. Alexander…[et al.]. The Role of GABAergic Inhibition in Ocular Dominance Plasticity. Neural Plasticity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-468465
American Medical Association (AMA)
Heimel, J. Alexander& van Versendaal, Daniëlle& Levelt, Christiaan N.. The Role of GABAergic Inhibition in Ocular Dominance Plasticity. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-468465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468465