Is There a Role for HTLV-1-Specific CTL in Adult T-Cell LeukemiaLymphoma?
Joint Authors
Bangham, Charles R. M.
Rowan, Aileen G.
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
ATLL is an aggressive malignancy of T cells that affects about 5% of individuals infected with HTLV-1.
The precise mechanism of oncogenesis is not known, but there is evidence that two regulatory viral proteins, Tax and HBZ, are involved.
A high set point proviral load is associated with development of ATLL or a chronic inflammatory condition, HAM/TSP.
Several lines of evidence, including HLA class 1 association studies and in vitro killing assays, indicate that cytotoxic T lymphocytes are instrumental in determining this proviral load set point.
Prior studies have focused chiefly on the CTL response to the immunodominant Tax protein: efficient lysis of Tax-expressing cells inversely correlates with proviral load in nonmalignant infection.
However, a recent study showed that strong binding of peptides from HBZ, but not Tax, to HLA class 1 molecules was associated with a low proviral load and a reduced risk of developing HAM/TSP, indicating an important role for HBZ-specific CTL in determining infection outcome.
In comparison with nonmalignant infection, HTLV-1-specific CTLs in ATLL patients are reduced in frequency and functionally deficient.
Here we discuss the nature of protective CTL responses in nonmalignant HTLV-1 infection and explore the potential of CTLs to protect against ATLL.
American Psychological Association (APA)
Rowan, Aileen G.& Bangham, Charles R. M.. 2011. Is There a Role for HTLV-1-Specific CTL in Adult T-Cell LeukemiaLymphoma?. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468488
Modern Language Association (MLA)
Rowan, Aileen G.& Bangham, Charles R. M.. Is There a Role for HTLV-1-Specific CTL in Adult T-Cell LeukemiaLymphoma?. Leukemia Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-468488
American Medical Association (AMA)
Rowan, Aileen G.& Bangham, Charles R. M.. Is There a Role for HTLV-1-Specific CTL in Adult T-Cell LeukemiaLymphoma?. Leukemia Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468488