Assessment of the Effects of Zoledronic Acid Therapy on Bone Metabolic Indicators in Hormone-Resistant Prostate Cancer Patients with Bone Metastatasis
Joint Authors
Tatlışen, Atila
Şahin, Nurettin
Ekmekcioglu, Oguz
Demirtas, Abdullah
Caniklioglu, Mehmet
Kula, Mustafa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
Assessment of effects of zoledronic acid therapy on bone metabolic indicators in hormone-resistant prostate cancer patients with bone metastasis.
Material and Methods.
Hormone-resistant prostate cancer patients who were identified to have metastases in their bone scintigraphy were taken to trial group.
Before administration of zoledronic acid, routine tests for serum calcium, total alkalen phosphates were studied.
Sample sera for bone metabolic indicators BALP, PINP, and ICTP were collected.
Bone pain was assessed via visual analogue scale and performance via Karnofsky performance scale.
Four mg zoledronic acid was administered intravenously once a month.
Results.
When serum levels of bone forming indicators PINP; BALP were compared before and after therapy, there were insignificant decreases (P=.33, P=.21, resp.).
Serum levels of bone destruction indicator ICTP was compared, and there was a significant decrease after zoledronic acid therapy (P=.04).
When performances of the patients were compared during therapy period, performances decreased significantly due to progress of illness (P=.01).
All patients had ostalgia caused by bone metastases at various degrees.
Significant decrease in pain scores was observed (P<.01).
Conclusion.
Zoledronic acid therapy decreased bone destruction and was effective in palliation of pain in patient with bone metastasis.
Using bone metabolic indicators during followup of zoledronic acid therapy might be useful.
American Psychological Association (APA)
Demirtas, Abdullah& Şahin, Nurettin& Caniklioglu, Mehmet& Kula, Mustafa& Ekmekcioglu, Oguz& Tatlışen, Atila. 2011. Assessment of the Effects of Zoledronic Acid Therapy on Bone Metabolic Indicators in Hormone-Resistant Prostate Cancer Patients with Bone Metastatasis. ISRN Urology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-468497
Modern Language Association (MLA)
Demirtas, Abdullah…[et al.]. Assessment of the Effects of Zoledronic Acid Therapy on Bone Metabolic Indicators in Hormone-Resistant Prostate Cancer Patients with Bone Metastatasis. ISRN Urology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-468497
American Medical Association (AMA)
Demirtas, Abdullah& Şahin, Nurettin& Caniklioglu, Mehmet& Kula, Mustafa& Ekmekcioglu, Oguz& Tatlışen, Atila. Assessment of the Effects of Zoledronic Acid Therapy on Bone Metabolic Indicators in Hormone-Resistant Prostate Cancer Patients with Bone Metastatasis. ISRN Urology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-468497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468497