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Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation
Joint Authors
Patil, Amod S.
Shirkhedkar, Atul A.
Khan, Zamir G.
Source
International Journal of Spectroscopy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Four simple, rapid, accurate, precise, reliable, and economical UV-spectrophotometric methods have been proposed for the determination of tadalafil in bulk and in pharmaceutical formulation.
“Method A” is first order derivative UV spectrophotometry using amplitude, “method B” is first order derivative UV spectrophotometry using area under curve technique, “method C” is second order derivative UV spectrophotometry using amplitude, and “method D” is second order derivative UV spectrophotometry using area under curve technique.
The developed methods have shown best results in terms of linearity, accuracy, precision, and LOD and LOQ for bulk drug and marketed formulation as well.
In N,N-dimethylformamide, tadalafil showed maximum absorbance at 284 nm.
For “method A” amplitude was recorded at 297 nm while for “method B” area under curve was integrated in the wavelength range of 290.60–304.40 nm.
For “method C” amplitude was measured at 284 nm while for “method D” area under curve was selected in the wavelength range of 280.80–286.20 nm.
For methods A and B, tadalafil obeyed Lambert-Beer’s law in the range of 05–50 μg/mL while for “methods C and D”, tadalafil obeyed Lambert-Beer’s law in the range of 20–70 μg/mL, and-for “methods A, B, C, and D” the correlation coefficients were found to be > than 0.999.
American Psychological Association (APA)
Khan, Zamir G.& Patil, Amod S.& Shirkhedkar, Atul A.. 2014. Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation. International Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-468526
Modern Language Association (MLA)
Khan, Zamir G.…[et al.]. Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation. International Journal of Spectroscopy No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-468526
American Medical Association (AMA)
Khan, Zamir G.& Patil, Amod S.& Shirkhedkar, Atul A.. Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation. International Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-468526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468526