Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure
Joint Authors
Pourmoghaddas, Ali
Bahmani, Alireza
Mahmoudi, Hamideh
Gharipour, Mojagn
Mirdamadi, Ahmad
Garakyaraghi, Mohammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
According to the present evidences suggesting association between low testosterone level and prediction of reduced exercise capacity as well as poor clinical outcome in patients with heart failure, we sought to determine if testosterone therapy improves clinical and cardiovascular conditions as well as quality of life status in patients with stable chronic heart failure.
Methods.
A total of 50 male patients who suffered from congestive heart failure were recruited in a double-blind, placebo-controlled trial and randomized to receive an intramuscular (gluteal) long-acting androgen injection (1 mL of testosterone enanthate 250 mg/mL) once every four weeks for 12 weeks or receive intramuscular injections of saline (1 mL of 0.9% wt/vol NaCl) with the same protocol.
Results.
The changes in body weight, hemodynamic parameters, and left ventricular dimensional echocardiographic indices were all comparable between the two groups.
Regarding changes in diastolic functional state and using Tei index, this parameter was significantly improved.
Unlike the group received placebo, those who received testosterone had a significant increasing trend in 6-walk mean distance (6MWD) parameter within the study period (P=0.019).
The discrepancy in the trends of changes in 6MWD between study groups remained significant after adjusting baseline variables (mean square = 243.262, F index = 4.402, and P=0.045).
Conclusion.
Our study strengthens insights into the beneficial role of testosterone in improvement of functional capacity and quality of life in heart failure patients.
American Psychological Association (APA)
Mirdamadi, Ahmad& Garakyaraghi, Mohammad& Pourmoghaddas, Ali& Bahmani, Alireza& Mahmoudi, Hamideh& Gharipour, Mojagn. 2014. Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468527
Modern Language Association (MLA)
Mirdamadi, Ahmad…[et al.]. Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-468527
American Medical Association (AMA)
Mirdamadi, Ahmad& Garakyaraghi, Mohammad& Pourmoghaddas, Ali& Bahmani, Alireza& Mahmoudi, Hamideh& Gharipour, Mojagn. Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-468527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468527