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PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers : Current Status of Clinical Trials
Joint Authors
Impens, Ann Julie
Phillips, Kristine
Schiopu, Elena
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Systemic sclerosis- (SSc-) related vasculopathy, as manifested by Raynaud's Phenomenon (RP) and digital ulcers (DUs), is associated with significant impairment of the quality of life and morbidity.
The current vasoactive approach for SSc-RP, although employing vasodilators, is entirely off-label.
PDE-5 inhibitors improve peripheral circulation, are well tolerated, and are widely used for various forms of constrictive vasculopathies.
This class of medications has become one of the first lines of treatment of SSc-RP and SSc-DUs among rheumatologists that routinely treat SSc patients.
Due to the lack of robust randomized clinical trials of PDE-5 inhibitors in SSc-RP/DUs, the PDE-5 inhibitors have not been FDA approved for these particular indications, which constitutes a significant barrier to prescribing this category of drugs.
This paper reviews the current state of evidence-based knowledge in SSc-related vasculopathy and the use of PDE-5 inhibitors.
American Psychological Association (APA)
Impens, Ann Julie& Phillips, Kristine& Schiopu, Elena. 2011. PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers : Current Status of Clinical Trials. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-468540
Modern Language Association (MLA)
Impens, Ann Julie…[et al.]. PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers : Current Status of Clinical Trials. International Journal of Rheumatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-468540
American Medical Association (AMA)
Impens, Ann Julie& Phillips, Kristine& Schiopu, Elena. PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers : Current Status of Clinical Trials. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-468540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468540