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Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza
Joint Authors
Yu, Wen-Jen
Li, Ying-Xiao
Chan, Paul
Cheng, Juei-Tang
Liu, I-Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tanshinone IIA is one of the active principles in danshen (Salvia miltiorrhiza Bge) widely used in treatment of cardiovascular disorders.
We investigated the effect of danshen or tanshinone IIA on blood pressure and its possible mechanisms.
An i.p.
injection of danshen at 10 mg kg−1 significantly lowered systolic blood pressure (SBP) of spontaneously hypertensive rats (SHRs) but failed to modify the SBP in normotensive Wistar-Kyoto rats (WKY).
Oral administration of tanshinone IIA also decreased SBP in SHR but not in WKY.
Tanshinone IIA produced a concentration-dependent relaxation in isolated SHR aortic rings precontracted with phenylephrine (10 nmol l−1) or potassium chloride (KCl) (40 mmol l−1).
The relaxing effect of tanshinone IIA on tonic contraction of phenylephrine in isolated aortic rings without endothelium remained produced.
Glibenclamide at concentration sufficient to block adenosine triphosphatase (ATP)-sensitive potassium (K+) channel attenuated this tanshinone IIA-induced relaxation that was not influenced by other inhibitors.
We further investigated the effect of tanshinone IIA on the changes of intracellular calcium concentration ([Ca2+]i) in cultured aortic smooth muscle (A7r5) cells using fura-2 as indicator.
Tanshinone IIA decreased [Ca2+]i elicited by phenylephrine (10 nmol l−1) or KCl (40 mmol l−1) in a concentration-dependent manner; glibenclamide, but not other inhibitors for K+ channel, abated this effect.
Our results suggest that tanshinone IIA acts as an active principle of danshen showing vasodilation through ATP-sensitive K+ channel to lower [Ca2+]i.
American Psychological Association (APA)
Chan, Paul& Liu, I-Min& Li, Ying-Xiao& Yu, Wen-Jen& Cheng, Juei-Tang. 2011. Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468548
Modern Language Association (MLA)
Chan, Paul…[et al.]. Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468548
American Medical Association (AMA)
Chan, Paul& Liu, I-Min& Li, Ying-Xiao& Yu, Wen-Jen& Cheng, Juei-Tang. Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468548