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The Stemness Phenotype Model
Joint Authors
Yakisich, Juan Sebastian
Calaf, Gloria M.
Siden, Åke
Delwar, Zahid M.
Cruz, Mabel H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The identification of a fraction of cancer stem cells (CSCs) associated with resistance to chemotherapy in most solid tumors leads to the dogma that eliminating this fraction will cure cancer.
Experimental data has challenged this simplistic and optimistic model.
Opposite to the classical cancer stem cell model, we introduced the stemness phenotype model (SPM), which proposed that all glioma cells possess stem cell properties and that the stemness is modulated by the microenvironment.
A key prediction of the SPM is that to cure gliomas all gliomas cells (CSCs and non-CSCs) should be eliminated at once.
Other theories closely resembling the SPM and its predictions have recently been proposed, suggesting that the SPM may be a useful model for other type of tumors.
Here, we review data from other tumors that strongly support the concepts of the SPM applied to gliomas.
We include data related to: (1) the presence of a rare but constant fraction of CSCs in established cancer cell lines, (2) the clonal origin of cancer, (3) the symmetrical division, (4) the ability of “non-CSCs” to generate “CSCs,” and (5) the effect of the microenvironment on cancer stemness.
The aforenamed issues that decisively supported the SPM proposed for gliomas can also be applied to breast, lung, prostate cancer, and melanoma and perhaps other tumors in general.
If the glioma SPM is correct and can be extrapolated to other types of cancer, it will have profound implications in the development of novel modalities for cancer treatment.
American Psychological Association (APA)
Cruz, Mabel H.& Siden, Åke& Calaf, Gloria M.& Delwar, Zahid M.& Yakisich, Juan Sebastian. 2012. The Stemness Phenotype Model. ISRN Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468549
Modern Language Association (MLA)
Cruz, Mabel H.…[et al.]. The Stemness Phenotype Model. ISRN Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-468549
American Medical Association (AMA)
Cruz, Mabel H.& Siden, Åke& Calaf, Gloria M.& Delwar, Zahid M.& Yakisich, Juan Sebastian. The Stemness Phenotype Model. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-468549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468549