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Hepatoprotective Effects of a Chinese Herbal Formula, Longyin Decoction, on Carbon-Tetrachloride-Induced Liver Injury in Chickens
Joint Authors
Li, Shuang
Zhang, Tie
Zhong, Xiuhui
Cui, Xuemei
Zhao, Xinghua
Wang, Chunguang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this study is to establish poultry liver injury model induced by (CCl4) and seek effective hepatoprotective herbals for clinical application.
Different doses of CCl4 dissolved in vegetable oil (1 : 1, V/V) were injected via pectoral muscle to induce acute liver injury model in chickens.
An herbal formula, Longyin decoction, was prepared for hepatoprotection test on chicken acute liver injury models.
The pathologic changes of the liver were observed, and the activities of ALT and AST were, respectively, detected to evaluate the hepatoprotective effects of Longyin decoction on chickens.
The chicken acute liver injury model was successfully established by injecting CCl4 via pectoral muscle.
The best dose of CCl4 inducing chicken liver injury was 4.0 mL/kg·BW (body weight).
The results of qualitative determination by HPTLC showed that the components of Longyin decoction contained Gentian, Capillaries, Gardenia, and Bupleurum root.
In the high-dose Longyin group and the middle-dose Longyin group, the pathological changes of the damaged liver were mitigated and the activities of ALT and AST in serum were reduced significantly.
Longyin decoction has obvious hepatoprotective effect on acute liver injury induced by CCl4.
American Psychological Association (APA)
Wang, Chunguang& Zhang, Tie& Cui, Xuemei& Li, Shuang& Zhao, Xinghua& Zhong, Xiuhui. 2013. Hepatoprotective Effects of a Chinese Herbal Formula, Longyin Decoction, on Carbon-Tetrachloride-Induced Liver Injury in Chickens. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468559
Modern Language Association (MLA)
Wang, Chunguang…[et al.]. Hepatoprotective Effects of a Chinese Herbal Formula, Longyin Decoction, on Carbon-Tetrachloride-Induced Liver Injury in Chickens. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-468559
American Medical Association (AMA)
Wang, Chunguang& Zhang, Tie& Cui, Xuemei& Li, Shuang& Zhao, Xinghua& Zhong, Xiuhui. Hepatoprotective Effects of a Chinese Herbal Formula, Longyin Decoction, on Carbon-Tetrachloride-Induced Liver Injury in Chickens. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468559