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Genetic Effects of Trabecular Titanium on MG-63 Cell Line : A Genetic Profiling Evaluation
Joint Authors
Hans Rudolf, Bloch
Francesca, Farinella
Silvia, Burelli
Ambra, Girardi
Vincenzo, Lorusso
Francesco, Carinci
Massari, Leo
Furio, Pezzetti
Vincenzo, Sollazzo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pure titanium and titanium alloys are materials widely used in orthopaedics because of their mechanical properties, chemical stability, and biocompatibility.
Recently, a new highly porous titanium biomaterial named Trabecular Titanium (TT) has been developed.
In this in vitro study, we tested the genetic effects of TT on osteoblast-like cells (MG63) using DNA microarrays technology: cDNA microarrays provides the ability to comparatively analyze mRNA expression of thousands of genes in parallel thus showing activated and repressed genes by the presence of the TT.
Several genes that were significantly up- or downregulated have been identified.
Globally, it was demonstrated that TT stimulates osteoblasts proliferation and differentiation, and reduces apoptosis.
Therefore, all these effects can contribute to improve the osseointegration of this material.
These results encourage the clinical application of Trabecular Titanium to prosthetic devices.
American Psychological Association (APA)
Vincenzo, Sollazzo& Massari, Leo& Furio, Pezzetti& Ambra, Girardi& Francesca, Farinella& Vincenzo, Lorusso…[et al.]. 2011. Genetic Effects of Trabecular Titanium on MG-63 Cell Line : A Genetic Profiling Evaluation. ISRN Materials Science،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-468564
Modern Language Association (MLA)
Vincenzo, Sollazzo…[et al.]. Genetic Effects of Trabecular Titanium on MG-63 Cell Line : A Genetic Profiling Evaluation. ISRN Materials Science No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-468564
American Medical Association (AMA)
Vincenzo, Sollazzo& Massari, Leo& Furio, Pezzetti& Ambra, Girardi& Francesca, Farinella& Vincenzo, Lorusso…[et al.]. Genetic Effects of Trabecular Titanium on MG-63 Cell Line : A Genetic Profiling Evaluation. ISRN Materials Science. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-468564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468564