The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury
Joint Authors
Nath, Karl
Liu, Ruisheng
Juncos, Luis A.
Stec, David E.
Chandrashekar, Kiran
Juncos, Ramiro
Vera, Trinity
Lopez-Ruiz, Arnaldo
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Angiotensin II (AngII) causes hypertension (HTN) and promotes renal injury while simultaneously inducing reno-protective enzymes like heme oxygenase-1 (HO-1).
We examined the modulatory role of HO on sub-pressor angiotensin II (SP-AngII) induced renal inflammation and injury.
We first tested whether the SP-AngII-induced renal dysfunction, inflammation and injury are exacerbated by either preventing (chronic HO-1 inhibition) or reversing (late HO-1 inhibition) SP-AngII-induced HO (using tin protoporphyrin; SnPP).
We next examined whether additional chronic or late induction of SP-AngII-induced HO (using cobalt protoporphyrin; CoPP), prevents or ameliorates renal damage.
We found that neither chronic nor late SnPP altered blood pressure.
Chronic SnPP worsened SP-AngII-induced renal dysfunction, inflammation, injury and fibrosis, whereas late SnPP worsened renal dysfunction but not inflammation.
Chronic CoPP prevented HTN, renal dysfunction, inflammation and fibrosis, but surprisingly, not the NGAL levels (renal injury marker).
Late CoPP did not significantly alter SP-AngII-induced HTN, renal inflammation or injury, but improved renal function.
Thus, we conclude (a) endogenous HO may be an essential determining factor in SP-AngII induced renal inflammation, injury and fibrosis, (b) part of HO’s renoprotection may be independent of blood pressure changes; and (c) further induction of HO-1 protects against renal injury, suggesting a possible therapeutic target.
American Psychological Association (APA)
Chandrashekar, Kiran& Lopez-Ruiz, Arnaldo& Juncos, Ramiro& Nath, Karl& Stec, David E.& Vera, Trinity…[et al.]. 2012. The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468575
Modern Language Association (MLA)
Chandrashekar, Kiran…[et al.]. The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury. International Journal of Hypertension No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-468575
American Medical Association (AMA)
Chandrashekar, Kiran& Lopez-Ruiz, Arnaldo& Juncos, Ramiro& Nath, Karl& Stec, David E.& Vera, Trinity…[et al.]. The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468575