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Ontogenetic Survey of Histone Modifications in an Annelid
Joint Authors
Pierce, Robyn
Hart, Corban
Lloyd, Vett K.
Gibson, Glenys
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Histone modifications are widely recognized for their fundamental importance in regulating gene expression in embryonic development in a wide range of eukaryotes, but they have received relatively little attention in the development of marine invertebrates.
We surveyed histone modifications throughout the development of a marine annelid, Polydora cornuta, to determine if modifications could be detected immunohistochemically and if there were characteristic changes in modifications throughout ontogeny (surveyed at representative stages from oocyte to adult).
We found a common time of onset for three histone modifications in early cleavage (H3K14ac, H3K9me, and H3K4me2), some differences in the distribution of modifications among germ layers, differences in epifluorescence intensity in specific cell lineages suggesting that hyperacetylation (H3K14ac) and hypermethylation (H3K9me) occur during differentiation, and an overall decrease in the distribution of modifications from larvae to adults.
Although preliminary, these results suggest that histone modifications are involved in activating early development and differentiation in a marine invertebrate.
American Psychological Association (APA)
Gibson, Glenys& Hart, Corban& Pierce, Robyn& Lloyd, Vett K.. 2012. Ontogenetic Survey of Histone Modifications in an Annelid. Genetics Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-468576
Modern Language Association (MLA)
Gibson, Glenys…[et al.]. Ontogenetic Survey of Histone Modifications in an Annelid. Genetics Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-468576
American Medical Association (AMA)
Gibson, Glenys& Hart, Corban& Pierce, Robyn& Lloyd, Vett K.. Ontogenetic Survey of Histone Modifications in an Annelid. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-468576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468576