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Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent
Joint Authors
Dahlin, Lars B.
Mårtensson, Lisa B.
Lindwall Blom, Charlotta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We investigated (a) if activation of the mitogen activated protein kinase (MAPK) pathway was linked to the stress activated protein kinase (SAPK) pathway and (b) if JNK was required for activation of c-Jun in Schwann cells of rat sciatic nerve following injury.
To this aim, ERK1/2 and the transcription factors c-Jun and ATF-3 were studied by immunohistochemistry in segments of transected nerves.
We utilized pharmacological inhibitors of both signal transduction pathways in vitro to determine the effects on downstream signalling events, such as c-Jun activation, and on Schwann cell survival and proliferation.
A transection induces c-Jun and ATF-3 transcription in Schwann cells.
These events are followed by Schwann cell activation of c-Jun in the injured nerve.
The MAPK inhibitor U0126 blocked ERK1/2 activation and reduced Schwann cell proliferation as well as induction of c-Jun transcription.
The JNK inhibitor SP600125 reduced Schwann cell proliferation, but did not affect the expression of ERK1/2 or injury-induced increases in c-Jun or ATF-3 levels.
Importantly, nerve injury induces Schwann cell activation of c-Jun by phosphorylation, which, in contrast to in sensory neurons, is JNK independent.
MAP kinases, other than JNK, can potentially activate c-Jun in Schwann cells following injury; information that is crucial to create new nerve reconstruction strategies.
American Psychological Association (APA)
Lindwall Blom, Charlotta& Mårtensson, Lisa B.& Dahlin, Lars B.. 2014. Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-468579
Modern Language Association (MLA)
Lindwall Blom, Charlotta…[et al.]. Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-468579
American Medical Association (AMA)
Lindwall Blom, Charlotta& Mårtensson, Lisa B.& Dahlin, Lars B.. Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-468579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468579