Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent

Joint Authors

Dahlin, Lars B.
Mårtensson, Lisa B.
Lindwall Blom, Charlotta

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-04-28

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

We investigated (a) if activation of the mitogen activated protein kinase (MAPK) pathway was linked to the stress activated protein kinase (SAPK) pathway and (b) if JNK was required for activation of c-Jun in Schwann cells of rat sciatic nerve following injury.

To this aim, ERK1/2 and the transcription factors c-Jun and ATF-3 were studied by immunohistochemistry in segments of transected nerves.

We utilized pharmacological inhibitors of both signal transduction pathways in vitro to determine the effects on downstream signalling events, such as c-Jun activation, and on Schwann cell survival and proliferation.

A transection induces c-Jun and ATF-3 transcription in Schwann cells.

These events are followed by Schwann cell activation of c-Jun in the injured nerve.

The MAPK inhibitor U0126 blocked ERK1/2 activation and reduced Schwann cell proliferation as well as induction of c-Jun transcription.

The JNK inhibitor SP600125 reduced Schwann cell proliferation, but did not affect the expression of ERK1/2 or injury-induced increases in c-Jun or ATF-3 levels.

Importantly, nerve injury induces Schwann cell activation of c-Jun by phosphorylation, which, in contrast to in sensory neurons, is JNK independent.

MAP kinases, other than JNK, can potentially activate c-Jun in Schwann cells following injury; information that is crucial to create new nerve reconstruction strategies.

American Psychological Association (APA)

Lindwall Blom, Charlotta& Mårtensson, Lisa B.& Dahlin, Lars B.. 2014. Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-468579

Modern Language Association (MLA)

Lindwall Blom, Charlotta…[et al.]. Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-468579

American Medical Association (AMA)

Lindwall Blom, Charlotta& Mårtensson, Lisa B.& Dahlin, Lars B.. Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-468579

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-468579