Adipose Tissue Dysfunction in Nascent Metabolic Syndrome
Joint Authors
Bremer, Andrew A.
Jialal, Ishwarlal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The metabolic syndrome (MetS) confers an increased risk for both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).
Moreover, studies on adipose tissue biology in nascent MetS uncomplicated by T2DM and/or CVD are scanty.
Recently, we demonstrated that adipose tissue dysregulation and aberrant adipokine secretion contribute towards the syndrome’s low-grade chronic proinflammatory state and insulin resistance.
Specifically, we have made the novel observation that subcutaneous adipose tissue (SAT) in subjects with nascent MetS has increased macrophage recruitment with cardinal crown-like structures.
We have also shown that subjects with nascent MetS have increased the levels of SAT-secreted adipokines (IL-1, IL-6, IL-8, leptin, RBP-4, CRP, SAA, PAI-1, MCP-1, and chemerin) and plasma adipokines (IL-1, IL-6, leptin, RBP-4, CRP, SAA, and chemerin), as well as decreased levels of plasma adiponectin and both plasma and SAT omentin-1.
The majority of these abnormalities persisted following correction for increased adiposity.
Our data, as well as data from other investigators, thus, highlight the importance of subcutaneous adipose tissue dysfunction in subjects with MetS and its contribution to the proinflammatory state and insulin resistance.
This adipokine profile may contribute to increased insulin resistance and low-grade inflammation, promoting the increased risk of T2DM and CVD.
American Psychological Association (APA)
Bremer, Andrew A.& Jialal, Ishwarlal. 2013. Adipose Tissue Dysfunction in Nascent Metabolic Syndrome. Journal of Obesity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468591
Modern Language Association (MLA)
Bremer, Andrew A.& Jialal, Ishwarlal. Adipose Tissue Dysfunction in Nascent Metabolic Syndrome. Journal of Obesity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-468591
American Medical Association (AMA)
Bremer, Andrew A.& Jialal, Ishwarlal. Adipose Tissue Dysfunction in Nascent Metabolic Syndrome. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468591