A Pilot Study of Mifepristone in Combat-Related PTSD
Joint Authors
Golier, Julia A.
DeMaria, Rebecca
Yehuda, Rachel
Caramanica, Kimberly
Source
Depression Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
We obtained pilot data to examine the clinical and neuroendocrine effects of short-term mifepristone treatment in male veterans with PTSD.
Methods.
Eight male veterans with military-related PTSD completed a randomized, double-blind trial of one week of treatment with mifepristone (600 mg/day) or placebo.
The primary clinical outcome measures were improvement in PTSD symptoms and dichotomously defined clinical responder status as measured by the CAPS at one-month follow-up.
Additional outcome measures included self-reported measures of PTSD symptom severity, CAPS-2 symptom subscale scores, and morning plasma cortisol and ACTH levels.
Results.
Mifepristone was associated with significant improvements in total CAPS-2 score.
At one-month follow-up, all four veterans in the mifepristone group and one of four veterans in the placebo group achieved clinical response; three of four veterans in the mifepristone group and one of four veterans in the mifepristone group remitted.
Mifepristone treatment was associated with acute increases in cortisol and ACTH levels and decreases in cytosolic glucocorticoid receptor number in lymphocytes.
Conclusions.
Further controlled trials of the effects of mifepristone and their durability are indicated in PTSD.
If effective, a short-term pharmacological treatment in PTSD could have myriad uses.
American Psychological Association (APA)
Golier, Julia A.& Caramanica, Kimberly& DeMaria, Rebecca& Yehuda, Rachel. 2012. A Pilot Study of Mifepristone in Combat-Related PTSD. Depression Research and Treatment،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-468593
Modern Language Association (MLA)
Golier, Julia A.…[et al.]. A Pilot Study of Mifepristone in Combat-Related PTSD. Depression Research and Treatment No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-468593
American Medical Association (AMA)
Golier, Julia A.& Caramanica, Kimberly& DeMaria, Rebecca& Yehuda, Rachel. A Pilot Study of Mifepristone in Combat-Related PTSD. Depression Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-468593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468593