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Electroacupuncture Inhibition of Hyperalgesia in Rats with Adjuvant Arthritis : Involvement of Cannabinoid Receptor 1 and Dopamine Receptor Subtypes in Striatum
Joint Authors
Zhao, Ying-Qian
Yang, Yang
Shou, Yin
Ge, Lin-Bao
Zhang, Bi-meng
Xu, Ming-Shu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Electroacupuncture (EA) has been regarded as an alternative treatment for inflammatory pain for several decades.
However, the molecular mechanisms underlying the antinociceptive effect of EA have not been thoroughly clarified.
Previous studies have shown that cannabinoid CB1 receptors are related to pain relief.
Accumulating evidence has shown that the CB1 and dopamine systems sometimes interact and may operate synergistically in rat striatum.
To our knowledge, dopamine D1/D2 receptors are involved in EA analgesia.
In this study, we found that repeated EA at Zusanli (ST36) and Kunlun (BL60) acupoints resulted in marked improvements in thermal hyperalgesia.
Both western blot assays and FQ-PCR analysis results showed that the levels of CB1 expression in the repeated-EA group were much higher than those in any other group (P=0.001).
The CB1-selective antagonist AM251 inhibited the effects of repeated EA by attenuating the increases in CB1 expression.
The two kinds of dopamine receptors imparted different actions on the EA-induced CB1 upregulation in AA rat model.
These results suggested that the strong activation of the CB1 receptor after repeated EA resulted in the concomitant phenomenon of the upregulation of D1 and D2 levels of gene expression.
American Psychological Association (APA)
Shou, Yin& Yang, Yang& Xu, Ming-Shu& Zhao, Ying-Qian& Ge, Lin-Bao& Zhang, Bi-meng. 2013. Electroacupuncture Inhibition of Hyperalgesia in Rats with Adjuvant Arthritis : Involvement of Cannabinoid Receptor 1 and Dopamine Receptor Subtypes in Striatum. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468603
Modern Language Association (MLA)
Shou, Yin…[et al.]. Electroacupuncture Inhibition of Hyperalgesia in Rats with Adjuvant Arthritis : Involvement of Cannabinoid Receptor 1 and Dopamine Receptor Subtypes in Striatum. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-468603
American Medical Association (AMA)
Shou, Yin& Yang, Yang& Xu, Ming-Shu& Zhao, Ying-Qian& Ge, Lin-Bao& Zhang, Bi-meng. Electroacupuncture Inhibition of Hyperalgesia in Rats with Adjuvant Arthritis : Involvement of Cannabinoid Receptor 1 and Dopamine Receptor Subtypes in Striatum. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468603