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Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury
Joint Authors
Goldberg, Peter
Husain, Sabah N. A.
Kishta, Osama A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gadolinium chloride (GdCl3), a Kupffer cells inhibitor, attenuates acute lung injury; however, the mechanisms behind this effect are not completely elucidated.
We tested the hypothesis that GdCl3 acts through the inhibition of lung parenchymal cellular apoptosis.
Two groups of rats were injected intraperitoneally with saline or E.
coli lipopolysaccharide.
In two additional groups, rats were injected with GdCl3 24 hrs prior to saline or LPS administration.
At 12 hrs, lung injury, inflammation, and apoptosis were studied.
Lung water content, myeloperoxidase activity, pulmonary apoptosis and mRNA levels of interleukin-1β, -2, -5, -6, -10 and TNF-α rose significantly in LPS-injected animals.
Pretreatment with GdCl3 significantly reduced LPS-induced elevation of pulmonary water content, myeloperoxidase activity, cleaved caspase-3 intensity, and attenuated pulmonary TUNEL-positive cells.
GdCl3 pre-treatment upregulated IL-1β, -2 and -10 pulmonary gene expression without significantly affecting the others.
These results suggest that GdCl3 attenuates acute lung injury through its effects on pulmonary parenchymal apoptosis.
American Psychological Association (APA)
Kishta, Osama A.& Goldberg, Peter& Husain, Sabah N. A.. 2012. Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury. ISRN Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-468605
Modern Language Association (MLA)
Kishta, Osama A.…[et al.]. Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury. ISRN Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-468605
American Medical Association (AMA)
Kishta, Osama A.& Goldberg, Peter& Husain, Sabah N. A.. Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury. ISRN Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-468605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468605