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Neuromyelitis Optica Spectrum Disease with Positive Autoimmune Indices : A Case Report and Review of the Literature
Joint Authors
Sfagos, C.
Koutsis, G.
Andreadou, E.
Evangelopoulos, Maria-Eleftheria
Potagas, C.
Dimirakopoulos, A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 45-year-old female suffering from severe thoracic pain was admitted to the emergency department of our hospital.
Thorough clinical examination revealed paresis of the left lower limb and sensory deficit at the level of the Th4 vertebra.
MRI of the thoracic spine demonstrated a lesion at the level of Th1–Th7.
Despite initial improvement following i.v.
corticosteroid administration, the patient's clinical status deteriorated, with recurrence of myelitis and extension of the lesion to Th12.
She developed paraparesis, hyperreflexia and spasticity of both legs, symmetrical sensory deficit below Th4, and sphincter dysfunction.
Differential diagnosis included infectious, metabolic, neoplastic/paraneoplastic, and ischemic causes as well as multiple sclerosis.
NMO IgG was found positive and led to the diagnosis of longitudinal extensive transverse myelitis (LETM) in the NMO spectrum disorders.
Administration of immunosuppressive therapy resulted in gradual improvement of the patient's clinical status and stabilization for five years.
In the setting of LETM, patients with antiaquaporin 4 IgGs can present features of coexisting systemic involvement.
A thorough differential diagnosis is required to guide appropriate therapy.
American Psychological Association (APA)
Evangelopoulos, Maria-Eleftheria& Koutsis, G.& Andreadou, E.& Potagas, C.& Dimirakopoulos, A.& Sfagos, C.. 2011. Neuromyelitis Optica Spectrum Disease with Positive Autoimmune Indices : A Case Report and Review of the Literature. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-468610
Modern Language Association (MLA)
Evangelopoulos, Maria-Eleftheria…[et al.]. Neuromyelitis Optica Spectrum Disease with Positive Autoimmune Indices : A Case Report and Review of the Literature. Case Reports in Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-468610
American Medical Association (AMA)
Evangelopoulos, Maria-Eleftheria& Koutsis, G.& Andreadou, E.& Potagas, C.& Dimirakopoulos, A.& Sfagos, C.. Neuromyelitis Optica Spectrum Disease with Positive Autoimmune Indices : A Case Report and Review of the Literature. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-468610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468610