Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from β-Lactoglobulin Secreted by Lactococcus lactis

Abstract EN

Previous studies showed that hydrolysates of β-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro.

In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system.

Interestingly, trypsin-digested recombinant BLG from L.

lactis inhibited DPP-IV activity, suggesting that BLG-secreting L.

lactis may be useful in the treatment of type 2 diabetes mellitus.