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Phase III Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV : Lessons Learnt
Joint Authors
Macpherson, Janet L.
Symonds, Geoff P.
Zack, Jerome A.
Mitsuyasu, Ronald T.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Gene therapy for individuals infected with HIV has the potential to provide a once-only treatment that will act to reduce viral load, preserve the immune system, and mitigate cumulative toxicities associated with highly active antiretroviral therapy (HAART).
The authors have been involved in two clinical trials (phase I and phase II) using gene-modified adult hematopoietic stem cells (HSCs), and these are discussed as prototypic trials within the general field of HSC gene therapy trials for HIV.
Taken as a group these trials have shown (i) the safety of both the procedure and the anti-HIV agents themselves and (ii) the feasibility of the approach.
They point to the requirement for (i) the ability to transduce and infuse as many as possible gene-containing HSC and/or (ii) high engraftment and in vivo expansion of these cells, (iii) potentially increased efficacy of the anti-HIV agent(s) and (iv) automation of the cell processing procedure.
American Psychological Association (APA)
Mitsuyasu, Ronald T.& Zack, Jerome A.& Macpherson, Janet L.& Symonds, Geoff P.. 2011. Phase III Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV : Lessons Learnt. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468622
Modern Language Association (MLA)
Mitsuyasu, Ronald T.…[et al.]. Phase III Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV : Lessons Learnt. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468622
American Medical Association (AMA)
Mitsuyasu, Ronald T.& Zack, Jerome A.& Macpherson, Janet L.& Symonds, Geoff P.. Phase III Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV : Lessons Learnt. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468622