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Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration : Possible Implication in Parkinson's Disease Incidence
Joint Authors
Mauriño, R.
Herrera, Antonio
de Pablos, R. M.
Sarmiento, M.
Venero, J. L.
Cano, J.
Espinosa-Oliva, A. M.
Villarán, R. F.
Delgado-Cortés, M. J.
Arguelles, Sandro
Santiago, M.
Machado, A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor.
Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral inflammations have been used, such as IL-1β and the ulcerative colitis model, as well as insults to the dopaminergic system such as 6-hydroxydopamine or lipopolysaccharide.
In all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as IL-1β and TNF-α.
Increased permeability or disruption of the BBB, with overexpression of the ICAM-1 adhesion molecule and infiltration of circulating monocytes into the substantia nigra, is also involved, since the depletion of circulating monocytes prevents the effects of peripheral inflammation.
Data are reviewed in relation to epidemiological studies of PD.
American Psychological Association (APA)
Machado, A.& Herrera, Antonio& Venero, J. L.& Santiago, M.& de Pablos, R. M.& Villarán, R. F.…[et al.]. 2011. Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration : Possible Implication in Parkinson's Disease Incidence. Journal of Pregnancy،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-468629
Modern Language Association (MLA)
Machado, A.…[et al.]. Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration : Possible Implication in Parkinson's Disease Incidence. Journal of Pregnancy No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-468629
American Medical Association (AMA)
Machado, A.& Herrera, Antonio& Venero, J. L.& Santiago, M.& de Pablos, R. M.& Villarán, R. F.…[et al.]. Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration : Possible Implication in Parkinson's Disease Incidence. Journal of Pregnancy. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-468629
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468629