Towards Patient-Specific Modeling of Coronary Hemodynamics in Healthy and Diseased State
Joint Authors
van der Horst, Arjen
Rutten, Marcel C. M.
van't Veer, Marcel
van de Vosse, Frans N.
Pijls, Nico H. J.
Boogaard, Frits L.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
A model describing the primary relations between the cardiac muscle and coronary circulation might be useful for interpreting coronary hemodynamics in case multiple types of coronary circulatory disease are present.
The main contribution of the present study is the coupling of a microstructure-based heart contraction model with a 1D wave propagation model.
The 1D representation of the vessels enables patient-specific modeling of the arteries and/or can serve as boundary conditions for detailed 3D models, while the heart model enables the simulation of cardiac disease, with physiology-based parameter changes.
Here, the different components of the model are explained and the ability of the model to describe coronary hemodynamics in health and disease is evaluated.
Two disease types are modeled: coronary epicardial stenoses and left ventricular hypertrophy with an aortic valve stenosis.
In all simulations (healthy and diseased), the dynamics of pressure and flow qualitatively agreed with observations described in literature.
We conclude that the model adequately can predict coronary hemodynamics in both normal and diseased state based on patient-specific clinical data.
American Psychological Association (APA)
van der Horst, Arjen& Boogaard, Frits L.& van't Veer, Marcel& Rutten, Marcel C. M.& Pijls, Nico H. J.& van de Vosse, Frans N.. 2013. Towards Patient-Specific Modeling of Coronary Hemodynamics in Healthy and Diseased State. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-468631
Modern Language Association (MLA)
van der Horst, Arjen…[et al.]. Towards Patient-Specific Modeling of Coronary Hemodynamics in Healthy and Diseased State. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-468631
American Medical Association (AMA)
van der Horst, Arjen& Boogaard, Frits L.& van't Veer, Marcel& Rutten, Marcel C. M.& Pijls, Nico H. J.& van de Vosse, Frans N.. Towards Patient-Specific Modeling of Coronary Hemodynamics in Healthy and Diseased State. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-468631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468631