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The Expression and Functions of Toll-Like Receptors in Atherosclerosis
Joint Authors
Monaco, Claudia
Georgiou, Ektoras
Cole, Jennifer E.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-24
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Inflammation drives atherosclerosis.
Both immune and resident vascular cell types are involved in the development of atherosclerotic lesions.
The phenotype and function of these cells are key in determining the development of lesions.
Toll-like receptors are the most characterised innate immune receptors and are responsible for the recognition of exogenous conserved motifs on pathogens, and, potentially, some endogenous molecules.
Both endogenous and exogenous TLR agonists may be present in atherosclerotic plaques.
Engagement of toll-like receptors on immune and resident vascular cells can affect atherogenesis as signalling downstream of these receptors can elicit proinflammatory cytokine release, lipid uptake, and foam cell formation and activate cells of the adaptive immune system.
In this paper, we will describe the expression of TLRs on immune and resident vascular cells, highlight the TLR ligands that may act through TLRs on these cells, and discuss the consequences of TLR activation in atherosclerosis.
American Psychological Association (APA)
Cole, Jennifer E.& Georgiou, Ektoras& Monaco, Claudia. 2010. The Expression and Functions of Toll-Like Receptors in Atherosclerosis. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-468641
Modern Language Association (MLA)
Cole, Jennifer E.…[et al.]. The Expression and Functions of Toll-Like Receptors in Atherosclerosis. Mediators of Inflammation No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-468641
American Medical Association (AMA)
Cole, Jennifer E.& Georgiou, Ektoras& Monaco, Claudia. The Expression and Functions of Toll-Like Receptors in Atherosclerosis. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-468641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468641