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Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults
Joint Authors
Lwabi, Peter
Byakika-Kibwika, Pauline
Boffito, Marta
Nyakoojo, Wilson B.
Mayanja-Kizza, Harriet
Khoo, Saye
Okaba-Kayom, Violet
Back, David
Katabira, Elly
Lamorde, Mohammed
Merry, Concepta
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
We aimed to assess cardiac conduction safety of coadministration of the CYP3A4 inhibitor lopinavir/ritonavir (LPV/r) and the CYP3A4 substrate artemether-lumefantrine (AL) in HIV-positive Ugandans.
Methods.
Open-label safety study of HIV-positive adults administered single-dose AL (80/400 mg) alone or with LPV/r (400/100 mg).
Cardiac function was monitored using continuous electrocardiograph (ECG).
Results.
Thirty-two patients were enrolled; 16 taking LPV/r -based ART and 16 ART naïve.
All took single dose AL.
No serious adverse events were observed.
ECG parameters in milliseconds remained within normal limits.
QTc measurements did not change significantly over 72 hours although were higher in LPV/r arm at 24 (424 versus 406; P=.02) and 72 hours (424 versus 408; P=.004) after AL intake.
Conclusion.
Coadministration of single dose of AL with LPV/r was safe; however, safety of six-dose AL regimen with LPV/r should be investigated.
American Psychological Association (APA)
Byakika-Kibwika, Pauline& Lamorde, Mohammed& Lwabi, Peter& Nyakoojo, Wilson B.& Okaba-Kayom, Violet& Mayanja-Kizza, Harriet…[et al.]. 2011. Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-468643
Modern Language Association (MLA)
Byakika-Kibwika, Pauline…[et al.]. Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults. Chemotherapy Research and Practice No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-468643
American Medical Association (AMA)
Byakika-Kibwika, Pauline& Lamorde, Mohammed& Lwabi, Peter& Nyakoojo, Wilson B.& Okaba-Kayom, Violet& Mayanja-Kizza, Harriet…[et al.]. Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and LopinavirRitonavir in HIV-Infected Ugandan Adults. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-468643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468643