Lowly Expressed Ribosomal Protein S19 in the Feces of Patients with Colorectal Cancer
Joint Authors
Tu, Tien-Chien
Lee, Chia-Long
Chien, Chih-Cheng
Huang, Chi-Jung
Yang, Shung-Haur
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Colorectal cancer (CRC) has become one of the most common fatal cancers.
CRC tumorigenesis is a complex process involving multiple genetic changes to several sequential mutations or molecular alterations.
P53 is one of the most significant genes; its mutations account for more than half of all CRC.
Therefore, understanding the cellular genes that are directly or indirectly related to p53 is particularly crucial for investigating CRC tumorigenesis.
In this study, a p53-related ribosomal protein, ribosomal protein S19 (RPS19), obtained from the feces of CRC patients is evaluated by using specifically quantitative real-time PCR and knocked down in the colonic cell line by gene silencing.
This study found that CRC patients with higher expressions of RPS19 in their feces had a better prognosis and consistent expressions of RPS19 and BAX in their colonic cells.
In conclusion, the potential mechanism of RPS19 in CRC possibly involves cellular apoptosis through the BAX/p53 pathway, and the levels of fecal RPS19 may function as a prognostic predictor for CRC patients.
American Psychological Association (APA)
Chien, Chih-Cheng& Tu, Tien-Chien& Huang, Chi-Jung& Yang, Shung-Haur& Lee, Chia-Long. 2012. Lowly Expressed Ribosomal Protein S19 in the Feces of Patients with Colorectal Cancer. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468680
Modern Language Association (MLA)
Chien, Chih-Cheng…[et al.]. Lowly Expressed Ribosomal Protein S19 in the Feces of Patients with Colorectal Cancer. ISRN Gastroenterology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-468680
American Medical Association (AMA)
Chien, Chih-Cheng& Tu, Tien-Chien& Huang, Chi-Jung& Yang, Shung-Haur& Lee, Chia-Long. Lowly Expressed Ribosomal Protein S19 in the Feces of Patients with Colorectal Cancer. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468680