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Effects of Metformin on the Regulation of Free Fatty Acids in Insulin Resistance : A Double-Blind, Placebo-Controlled Study
Joint Authors
van Wijk, Jeroen P. H.
Elte, Jan Willem F.
Cabezas, Manuel Castro
Klop, Boudewijn
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Impaired free fatty acid (FFA) metabolism is closely linked to insulin resistance.
Our aim was to evaluate plasma FFA changes in insulin resistance in a physiological situation after improvement of insulin sensitivity by metformin.
Methods.
A double-blind, placebo-controlled intervention with metformin was carried out in patients with insulin resistance.
Nineteen patients were randomized to receive metformin 850 mg b.i.d.
during 6 weeks or placebo.
Participants underwent a mental stress test and an oral glucose tolerance test (OGTT) before and after treatment.
Results.
Fasting plasma glucose, FFA, and HOMA-IR tended to decrease after metformin, suggesting improved insulin sensitivity.
FFA concentrations during the mental stress test showed a similar pattern after metformin, albeit lower at all time points, in contrast to the placebo group.
The decrease in fasting plasma FFAs was positively associated to the decrease in HbA1c (r=0.70; P=0.03) and in fasting glucose (r=0.74; P=0.01).
The suppression of plasma FFAs during OGTT did not change by metformin or placebo.
Conclusion.
Metformin in insulin resistance did not lead to improved FFA dynamics despite a trend of improved insulin sensitivity.
Metformin most likely decreases plasma FFAs mainly by suppressing fasting FFA concentrations and not by suppression of acute stress-induced lipolysis.
American Psychological Association (APA)
Cabezas, Manuel Castro& van Wijk, Jeroen P. H.& Elte, Jan Willem F.& Klop, Boudewijn. 2012. Effects of Metformin on the Regulation of Free Fatty Acids in Insulin Resistance : A Double-Blind, Placebo-Controlled Study. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468690
Modern Language Association (MLA)
Cabezas, Manuel Castro…[et al.]. Effects of Metformin on the Regulation of Free Fatty Acids in Insulin Resistance : A Double-Blind, Placebo-Controlled Study. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-468690
American Medical Association (AMA)
Cabezas, Manuel Castro& van Wijk, Jeroen P. H.& Elte, Jan Willem F.& Klop, Boudewijn. Effects of Metformin on the Regulation of Free Fatty Acids in Insulin Resistance : A Double-Blind, Placebo-Controlled Study. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-468690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468690