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Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes
Joint Authors
Paquette, Carmen
Hould, Frédéric-Simon
Simard, Serge
Martin, Julie
Dumesnil, Jean-Gaston
Marceau, Simon
Poirier, Paul
Lebel, Stéfane
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Determine the impact of Orlistat-induced weight loss on metabolic profile and cardiovascular function in severely obese patients with type 2 diabetes.
Methods.
Twenty-nine patients were randomized either to a nonplacebo control group or to a treatment group with Orlistat thrice a day.
Metabolic profile, anthropometric parameters, heart rate variability indices, and echocardiographic variables were measured before and after a 12-week treatment period.
Results.
Treatment with Orlistat induced a modest but significant weight loss compared to controls (3.7 ± 3.0 versus 0.5 ± 2.2 kg, resp.; P=.003).
There was significant decrease in fasting glycemia (7.9 ± 3.0 versus 6.7 ± 2.2 mmol/L; P=.03) and significant improvements in left ventricular diastolic function (P=.03) and in the sympathovagal balance (LF/HF ratio) (P=.04) in the Orlistat group.
Conclusion.
These results suggest that a modest weight loss improves fasting glycemia, left ventricular diastolic function, and sympathovagal balance in severely obese patients with type 2 diabetes.
American Psychological Association (APA)
Martin, Julie& Paquette, Carmen& Marceau, Simon& Hould, Frédéric-Simon& Lebel, Stéfane& Simard, Serge…[et al.]. 2010. Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes. Journal of Obesity،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468694
Modern Language Association (MLA)
Martin, Julie…[et al.]. Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes. Journal of Obesity No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-468694
American Medical Association (AMA)
Martin, Julie& Paquette, Carmen& Marceau, Simon& Hould, Frédéric-Simon& Lebel, Stéfane& Simard, Serge…[et al.]. Impact of Orlistat-Induced Weight Loss on Diastolic Function and Heart Rate Variability in Severely Obese Subjects with Diabetes. Journal of Obesity. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-468694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468694