![](/images/graphics-bg.png)
Arterial and Venous Thrombosis in Cancer Patients
Joint Authors
Blann, Andrew D.
Dunmore, Simon
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The most frequent ultimate cause of death is myocardial arrest.
In many cases this is due to myocardial hypoxia, generally arising from failure of the coronary macro- and microcirculation to deliver enough oxygenated red cells to the cardiomyocytes.
The principle reason for this is occlusive thrombosis, either by isolated circulating thrombi, or by rupture of upstream plaque.
However, an additionally serious pathology causing potentially fatal stress to the heart is extra-cardiac disease, such as pulmonary hypertension.
A primary cause of the latter is pulmonary embolus, considered to be a venous thromboembolism.
Whilst the thrombotic scenario has for decades been the dominating paradigm in cardiovascular disease, these issues have, until recently, been infrequently considered in cancer.
However, there is now a developing view that cancer is also a thrombotic disease, and notably a disease predominantly of the venous circulation, manifesting as deep vein thrombosis and pulmonary embolism.
Indeed, for many, a venous thromboembolism is one of the first symptoms of a developing cancer.
Furthermore, many of the standard chemotherapies in cancer are prothrombotic.
Accordingly, thromboprophylaxis in cancer with heparins or oral anticoagulation (such as Warfarin), especially in high risk groups (such as those who are immobile and on high dose chemotherapy), may be an important therapy.
The objective of this communication is to summarise current views on the epidemiology and pathophysiology of arterial and venous thrombosis in cancer.
American Psychological Association (APA)
Blann, Andrew D.& Dunmore, Simon. 2011. Arterial and Venous Thrombosis in Cancer Patients. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-468704
Modern Language Association (MLA)
Blann, Andrew D.& Dunmore, Simon. Arterial and Venous Thrombosis in Cancer Patients. Cardiology Research and Practice No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-468704
American Medical Association (AMA)
Blann, Andrew D.& Dunmore, Simon. Arterial and Venous Thrombosis in Cancer Patients. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-468704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468704