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Antiherpetic Effects of Gynura procumbens
Joint Authors
Jarikasem, Siripen
Charuwichitratana, Somyot
Iskander, Magdy
Siritantikorn, Sontana
Chantratita, Wasan
Frahm, August Wilhelm
Jiratchariyakul, Weena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The ethanol extract of Gynura procumbens showed virucidal and antireplicative actions against herpes simplex virus HSV-1 and HSV-2.
It was further chromatographed on MCI gel CHP20P column giving the extract fractions F1 (water), F2 (water-methanol) F3 (methanol), and F4 (ethyl acetate).
All but F1 had virucidal action against both viral types.
We reported here the active compounds from F2 and F3.
The antiherpetic compounds of F2 was a mixture of dicaffeoylquinic acids with virucidal and antireplicative actions against HSV-2 (IC50 96.0 and 61.0 μg/mL, resp.) Virucidal compounds of F3 were a mixture of β-sitosterol and stigmasterol (IC50 250.0 μg/mL against HSV-1), a mixture of β-sitosteryl and stigmasteryl glucosides (IC50 50.0 μg/mL against HSV-2) and 1, 2-bis-dodecanoyl-3-α-D-glucopyranosyl-sn-glycerol (IC50 of 40.0 μg/mL against HSV-2).
Herbal products containing 1 and 2% of standardized ethanol extract were prepared.
Double-blind randomized controlled clinical trial of the products was performed in patients with recurrent herpes labialis.
Results showed that the number of patients, whose lesions healed within 7 days and the average healing time of both groups differed insignificantly.
Viral culture on D7 indicated a decrease of infected patients from 48.7% to 7.69% in treated group whereas in placebo group the infected patients decreased from 31.25% to 20.00%.
The viral reduction in treated group indicated the benefit of the product.
Insignificant result might arise from a low number of participated patients and insufficient concentration of plant extract in herbal product.
American Psychological Association (APA)
Jarikasem, Siripen& Charuwichitratana, Somyot& Siritantikorn, Sontana& Chantratita, Wasan& Iskander, Magdy& Frahm, August Wilhelm…[et al.]. 2013. Antiherpetic Effects of Gynura procumbens. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468720
Modern Language Association (MLA)
Jarikasem, Siripen…[et al.]. Antiherpetic Effects of Gynura procumbens. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-468720
American Medical Association (AMA)
Jarikasem, Siripen& Charuwichitratana, Somyot& Siritantikorn, Sontana& Chantratita, Wasan& Iskander, Magdy& Frahm, August Wilhelm…[et al.]. Antiherpetic Effects of Gynura procumbens. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-468720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468720