Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation
Joint Authors
Donini, Lorenzo Maria
Aversa, Antonio
Lenzi, Andrea
Francomano, Davide
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT).
20 men with LL-PE (18–40 years) were enrolled in an 8-week, double-blind, placebo-controlled, crossover study and compared with 10 age-matched controls without LL-PE.
Primary endpoints were PAT modifications induced by vardenafil 10 mg on demand.
Secondary endpoints were the improvement in intravaginal ejaculatory latency time (IELT) as measured by the stopwatch technique and variations in anxiety scores at Stai-X1 for state-anxiety and Stai-X2 for trait-anxiety.
At baseline, men with LL-PE showed higher RHI variation (P<0.001), Stai-X1 and Stai X2 scores (P<0.0001, resp.), and prolactin levels (P<0.05) compared with controls.
Vardenafil treatment markedly reduced RHI variation in men with LL-PE (P<0.01) when compared with placebo.
Mean changes in geometric IELT were higher after taking vardenafil (0.6 ± 0.3 versus 4.5 ± 1.1 min, P<0.01) when compared with placebo.
STAI-X1 and STAI-X2 scores fell within the normal range after treatment with vardenafil (P<0.01).
Vardenafil was an effective treatment in men with LL-PE; improvements of IELT may be due to increased NO production which is able to reduce adrenergic overactivity and anxiety levels.
American Psychological Association (APA)
Francomano, Davide& Donini, Lorenzo Maria& Lenzi, Andrea& Aversa, Antonio. 2013. Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468726
Modern Language Association (MLA)
Francomano, Davide…[et al.]. Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation. International Journal of Endocrinology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-468726
American Medical Association (AMA)
Francomano, Davide& Donini, Lorenzo Maria& Lenzi, Andrea& Aversa, Antonio. Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468726