Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet
Joint Authors
Bacurau, Reury F. P.
Camara, Niels Olsen Saraiva
Araújo, Ronaldo C.
Barros, Carlos C.
Paredes-Gamero, Edgar J.
Wasinski, Frederick
Moraes-Vieira, Pedro M. M.
Estrela, Gabriel R.
Haro, Anderson S.
Moraes, Milton R.
Almeida, Sandro S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
As the size of adipocytes increases during obesity, the establishment of resident immune cells in adipose tissue becomes an important source of proinflammatory mediators.
Exercise and caloric restriction are two important, nonpharmacological tools against body mass increase.
To date, their effects on the immune cells of adipose tissue in obese organisms, specifically when a high-fat diet is consumed, have been poorly investigated.
Thus, after consuming a high-fat diet, mice were submitted to chronic swimming training or a 30% caloric restriction in order to investigate the effects of both interventions on resident immune cells in adipose tissue.
These strategies were able to reduce body mass and resulted in changes in the number of resident immune cells in the adipose tissue and levels of cytokines/chemokines in serum.
While exercise increased the number of NK cells in adipose tissue and serum levels of IL-6 and RANTES, caloric restriction increased the CD4+/CD8+ cell ratio and MCP-1 levels.
Together, these data demonstrated that exercise and caloric restriction modulate resident immune cells in adipose tissues differently in spite of an equivalent body weight reduction.
Additionally, the results also reinforce the idea that a combination of both strategies is better than either individually for combating obesity.
American Psychological Association (APA)
Wasinski, Frederick& Bacurau, Reury F. P.& Moraes, Milton R.& Haro, Anderson S.& Moraes-Vieira, Pedro M. M.& Estrela, Gabriel R.…[et al.]. 2013. Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468775
Modern Language Association (MLA)
Wasinski, Frederick…[et al.]. Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-468775
American Medical Association (AMA)
Wasinski, Frederick& Bacurau, Reury F. P.& Moraes, Milton R.& Haro, Anderson S.& Moraes-Vieira, Pedro M. M.& Estrela, Gabriel R.…[et al.]. Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-468775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468775