Serotonin Transporter Clustering in Blood Lymphocytes of Reeler Mice
Joint Authors
Rivera-Baltanas, Tania
Caruncho, Héctor J.
Romay-Tallón, Raquel
Dopeso-Reyes, Iria G.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Serotonin transporter clustering is an important feature for regulation of this transporter activity.
We used immunocytochemistry to analyze alterations in serotonin transporter clustering in blood lymphocytes of reeler mice.
Serotonin transporter immunolabelling is observed mostly as a patchy staining in lymphocytes membranes.
Comparison of the number and size of serotonin transporter clusters in wild-type mice, heterozygous reeler mice, and homozygous reeler mice showed an increase in the number and size of clusters in heterozygous reeler mice, but only an increase in clusters size in homozygous reeler mice.
Reelin is down-regulated in the brain of schizophrenia, autism, and mood disorders, and is also expressed in blood plasma.
There is the possibility therefore that alterations in serotonin transporter clustering in blood lymphocytes associated with a decrease in reelin expression may be operative in some cardiovascular or immune system alterations showing comorbidity with these mental disorders.
American Psychological Association (APA)
Rivera-Baltanas, Tania& Romay-Tallón, Raquel& Dopeso-Reyes, Iria G.& Caruncho, Héctor J.. 2010. Serotonin Transporter Clustering in Blood Lymphocytes of Reeler Mice. Cardiovascular Psychiatry and Neurology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-468830
Modern Language Association (MLA)
Rivera-Baltanas, Tania…[et al.]. Serotonin Transporter Clustering in Blood Lymphocytes of Reeler Mice. Cardiovascular Psychiatry and Neurology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-468830
American Medical Association (AMA)
Rivera-Baltanas, Tania& Romay-Tallón, Raquel& Dopeso-Reyes, Iria G.& Caruncho, Héctor J.. Serotonin Transporter Clustering in Blood Lymphocytes of Reeler Mice. Cardiovascular Psychiatry and Neurology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-468830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468830