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Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound
Joint Authors
Morrison, Carl D.
Durrani, Farukh A.
Tóth, Károly
Cao, Shousong
Rustum, Youcef M.
Seshadri, Mukund
Bhattacharya, Arup
Stott, Emily
Sen, Arindam
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Tumor differentiation enhances morphologic and microvascular heterogeneity fostering hypoxia that retards intratumoral drug delivery, distribution, and compromise therapeutic efficacy.
In this study, the influence of tumor biologic heterogeneity on the interaction between cytotoxic chemotherapy and selenium was examined using a panel of human tumor xenografts representing cancers of the head and neck and lung along with tissue microarray analysis of human surgical samples.
Tumor differentiation status, microvessel density, interstitial fluid pressure, vascular phenotype, and drug delivery were correlated with the degree of enhancement of chemotherapeutic efficacy by selenium.
Marked potentiation of antitumor activity was observed in H69 tumors that exhibited a well-vascularized, poorly differentiated phenotype.
In comparison, modulation of chemotherapeutic efficacy by antiangiogenic selenium was generally lower or absent in well-differentiated tumors with multiple avascular hypoxic, differentiated regions.
Tumor histomorphologic heterogeneity was found prevalent in the clinical samples studied and represents a primary and critical physiological barrier to chemotherapy.
American Psychological Association (APA)
Rustum, Youcef M.& Tóth, Károly& Seshadri, Mukund& Sen, Arindam& Durrani, Farukh A.& Stott, Emily…[et al.]. 2010. Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound. Journal of Oncology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-468831
Modern Language Association (MLA)
Rustum, Youcef M.…[et al.]. Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound. Journal of Oncology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-468831
American Medical Association (AMA)
Rustum, Youcef M.& Tóth, Károly& Seshadri, Mukund& Sen, Arindam& Durrani, Farukh A.& Stott, Emily…[et al.]. Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-468831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468831